Programme
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23 May 2024
| Time | Title |
|---|---|
| 13:00-14:00 | Registration, poster set-up and welcome snack |
| 14:00-14:30 |
Welcome
Jesús Requena (U. Santiago de Compostela) and Leticia Lucero (CNB-CSIC) |
| 14:30-14:45 |
SESSION 1: ANIMAL PRION DISEASES
Chairs: Nerea Larrañaga (U.Zaragoza) and Rebeca Benavente (UTHealth Houston)
|
| 14:45-15:30 |
Alicia Otero (U. Zaragoza)
Experimental prion diseases in large animals: The problems of cow-laboration in prion research |
| 15:30-15:45 |
Sara Canoyra (CISA-INIA-CSIC)
Evolution of Nor98/Atypical scrapie through transmission in a heterologous and homologous PrPC context
|
| 15:45-16:00 |
Natalia Fernández-Borges (CISA-INIA-CSIC)
Goat PrP-222K polymorphic variant generates silent carriers for classical scrapie prions |
| 16:00-16:15 |
Lucien van Keulen (Wageningen Bioveterinary Research, the Netherlands)
Change in the molecular properties of CH1641 prions after transmission to wild-type mice: evidence for a single strain |
| 16:15-16:45 | Coffee + Posters |
| 16:45-17:00 |
Glenn Telling (Prion Researh Center, Colorado State University)
Adaptive events in peripheral and intracerebral compartments of gene-targeted mice result in the selective propagation of CWD strains |
| 17:00-17:15 |
Nuria Jerez-Garrido (CISA-INIA-CSIC)
Chronic Wasting Disease in Bovine-PrP Transgenic Mice Propagates with Different Prion Strain Features |
| 17:15-17:30 |
Tomás Barrio (INRAE)
Zoonotic potential of moose-derived chronic wasting disease prions after adaptation in intermediate species |
| 17:30-17:45 |
Maria Rebeca Benavente (UTHealth Houston)
Detection of chronic wasting disease prions in processed meats and evaluations of zoonotic potentials |
| 17:45-18:00 |
Rodrigo Morales (UTHealth Houston)
CWD prions in the environment. New insights on how infectivity spreads in natural settings. |
| 18:00-18:15 |
Maria Rebeca Benavente (UTHealth Houston)
Development of a high-throughput system for the screening of anti-prion molecules |
| 18:15-18:30 |
Jason Bartz (Creighton University)
Alterations in prion mutant spectra precede strain breakdown in animals |
| 18:30-19:15 |
Carsten Korth (U. Düsseldorf) - Frontiers in Prion Research
DISC1 protein aggregates define a subset of chronic mental illnesses |
| 20:30- |
Social activity
Paris-Dakar Scavenger Hunt |
24 May 2024
| Time | Title |
|---|---|
| 9:00-9:15 |
Continuation ANIMAL PRION DISEASES
Chairs: Nerea Larrañaga (U.Zaragoza) and Rebeca Benavente (UTHealth Houston)
|
| 9:15-9:30 |
Sabine Gilch (U. Calgary)
Extraneural infection route restricts prion conformational variability and attenuates the impact of quaternary structure on infectivity |
| 09:30-09:45 |
SESSION 2: PRION STRUCTURE AND BIOLOGY
Chairs: Cristina Sampedro (CIC bioGUNE) and Sanaz Sabzehei (U. Santiago de Composela)
|
| 9:45-10:30 |
Jan Bieschke (MRC Prion Unit- UCL)
Prion replication – from structure to mechanism and back |
| 10:30-10:45 |
Szymon Manka (MRC Prion Unit- UCL)
Fluorescent prions in live cells: from real-time monitoring to nano-scale structural snapshots |
| 10:45-11:00 |
Nuria Lopez Lorenzo (U. Santiago de Compostela)
Further insights on “non-PrPSc” full length PrP prions |
| 11:00-11:15 |
Anna Burato (SISSA)
Electrophysiological characterization of primary cortical neurons devoid of the prion protein |
| 11:15-12:00 | Coffee Break + Posters! |
| 12:00-12:15 |
Maria Blanquer Gárate (CIMUS)
Potential impact of SUMO on Prion-related diseases |
| 12:15-12:30 |
Leticia Lucero (CNB-CSIC)
Characterization of WH1 amyloid domains in Rep proteins from Xylella fastidiosa plasmids |
| 12:30-12:45 |
Basile Fornara (INRAe)
The dynamics of prion spreading is governed by the interplay between the non-linearities of tissue response and replication kinetics |
| 12:45-15:00 | Lunch |
| 15:00-15:15 |
SESSION 3: PRION AND PRION-LIKE DISEASES IN HUMANS
Chairs: Leticia-Camila Fernández (U. Göttingen) and Nuno Gonçalves-Anjo (CICbioGUNE)
|
| 15:15-16:00 |
Inga Zerr (U. Göttingen)
Biochemical biomarkers for human prion diseases-needs and challenge |
| 16:00-16:15 |
Roberto Chiesa (Istituto di Ricerche Farmacologiche Mario Negri)
The cellular prion protein mediates tau oligomer-induced synaptotoxicity and memory impairment in mice |
| 16:15-16:30 |
Luigi Celauro (SISSA)
Different tau fibril types reduce prion level in chronically and de novo infected cells |
| 16:30-16:45 |
Juan Carlos Espinosa Martín ( CISA-INIA-CSIC)
Effect of Formic Acid Treatment in the Reduction of sCJD and vCJD Prion Infectivity |
| 16:45-17:15 | Coffee Break + Posters! |
| 17:15-17:30 |
Nicole Innocenti (U. Trento)
Chemical exploration of a PrP degrader compound |
| 17:30-17:45 |
Leticia Camila Fernandez-Flores (U. Göttingen)
Optimization of an exosome isolation technique based on nanotechnology to improve Alzheimer's disease diagnose |
| 17:45-18:00 |
Ilaria Zeni (U. Trento- CIBIO)
Light Identification of Protein Suppressors (LIPS) as a new technology to screen for pharmacological modulators of the cellular prion protein |
| 18:00-18:30 |
Sara González-Navarro, President (Spanish Prion Disease Foundation)
A Necessary Foundation |
| Closing ceremony | |
| 18:30-19:00 | Prizes |
| 19:00-19:15 | Presentation of the XIII Iberian Prion Conference |
| 19:15-19:30 |
Recapitulation
Jesús Requena (U. Santiago de Compostela) and Leticia Lucero (CNB-CSIC)
|
| 21:00 | Conference Symposium (networking with food) |